Serenaded with chants of "MVP", Derrick Rose poured in a game high 34 points leading the Chicago Bulls to a 99-96 win over the Miami Heat on Saturday.

LeBron James sat out a second straight game.

Sidelined with an ankle injury, James watched in street clothes from the end of the Miami bench as Kyle Korver nailed a key three-pointer with 25 seconds to play as the Heat slumped to a third consecutive defeat.

"This is a tough one," Miami coach Erik Spoelstra told reporters.

"On the road, this the kind of game you want. You have a chance to win, we had a chance at the end but they outplayed us in the effort areas."

Chicago native Dwyane Wade stepped up in James' absence hitting 33 points, including three consecutive three-pointers in the fourth quarter, but missed a jump shot at the buzzer that would have sent the game into overtime. Carlos Boozer and Luol Deng each contributed 12 points to the victory as the Bulls improved their home record to 18-3.

A capacity crowd of 23,072 packed the United Centre to watch James make his first visit to Chicago in a Miami uniform. James participated in the pre-game warm-up but had still not recovered enough from the ankle injury he sustained on Wednesday in a loss to the Los Angeles Clippers.

Bad news

There was more bad news for the Heat, who saw Chris Bosh crumble to the court in the third quarter. He was taken for X-rays, Spoelstra later describing the injury as a sprained ankle.

The Bulls had been heavily involved in the James summer sweepstakes before he decided to leave the Cleveland Cavaliers and "take his talents to South Beach".

Chicago also made a big pitch for Bosh and attempted to lure Wade back to Chicago. All three rejected Chicago's overtures but the Bulls have got on just fine without James and company, running away with the Central Division.

Chicago charged to a 28-19 first quarter and led by 13 midway through the second before the Heat caught fire, erasing the deficit and taking a 53-48 advantage into the intermission with the help of 21 points from Wade.

But the Bulls were again quick out of the gate going on a 17-0 run to open the second half to retake the lead 65-53.

The Heat clawed their way back once again, Bosh leading the rally with 11 of his 17 points as Miami trimmed the Chicago advantage to 73-70 going into the final quarter.

Elsewhere in NBA, it was: Grizzlies 89, Mavericks 70; Hornets 88, Bobcats 81; Rockets 112, Hawks 106; Magic 108, Timberwolves 99; Wizards 98, Raptors 95; Pistons 110, Kings 106; Nuggets 127, Cavaliers 99; and Trail Blazers 96, Nets 89.