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Sir Alex Ferguson the Manchester United manager looks on from the bench during the Barclays Premier League match between Queens Park Rangers and Manchester United at Loftus Road on December 18, 2011 in London, England.

Sir Alex Ferguson has refused to write off a challenge from London at the top of the Premier League in 2012 despite the dominance of Manchester's rival pacesetters.

A strong first half to the season from Manchester United and current league leader City has left many pundits predicting the eventual champion will come from Manchester.

However, although third-placed Tottenham is seven points behind Ferguson's second-placed team, Harry Redknapp's club has the luxury of a game in hand and history has taught the veteran United manager that challenges to their title could come from a variety of sources in the new year.

"At this moment in time, everyone thinks it will be one and two for the city," said Ferguson. "But come March, things change and you need to go back over the years to see how dramatic it can be.

"We surrendered an 11-point lead to Arsenal and we managed to claw back a 12-point deficit to Newcastle and last year Chelsea were 10 points clear in November and they lost it. You lose a game in this league and all the rest get a pick up and start chasing harder. That's the way the league is and come March, you never know."

United bounced back superbly in midweek, winning 5-0 at Fulham, to respond to critics who had a field day after the defending Premier League champion was unceremoniously dumped out of the Champions League by Swiss club Basel.

"The criticism has been understandable because you lose a derby game 6-1, you get knocked out of the League Cup by Crystal Palace, a Championship team, and you lose to Basel, which is not a power in Europe," said Ferguson.

"You can understand the criticism but in terms of the nature of the kind of player we have, the kind of club we are, we've got the resilience and determination to do something about it each time it's happened.

"I think that shows the character of the team. In a normal season we lose games but the games we've lost this season have been a bit more dramatic and more emphatic in the sense of the impact it has had on our chances of winning trophies.

"We're out of the Champions League, out of the League Cup and lost to City in a derby game. These are bad results for us, bad results, and the character of the team has rescued us each time.

"We've come back. Last season the focus was on our bad away form but the home form rescued us. We haven't had any away defeats and you wonder what's happened here because it's a tough league."

United face a home fixture against Wigan on Monday that would appear, on paper at least, to offer little obstacle to it continuing a run of seven wins and a draw in the eight games since its humiliating 6-1 home defeat to City.

However, it will have to contend without winger Ashley Young who has been ruled out for a "few weeks" with a knee injury.

Versatile Phil Jones has handed Ferguson a bonus with the news he could be fit to play against the Latics despite fears he had suffered a bad facial injury at Fulham.

After an away victory at West Brom and home draws with Chelsea and Liverpool, the Wigan manager, Roberto Martinez, wants his team to continue to show its steady improvement against United, in the more intimidating atmosphere of Old Trafford.

"The performances against Chelsea and Liverpool were very good. They weren't just accidents," he said.

"They showed what we can do, but the next game is going to be as big a test we've faced all season."